Journal of Vascular Nursing
Volume 21, Issue 1 , Pages 30-32 , March 2003

Hyperhomocysteinemia and vascular disease

References 

  1. American Heart Association AHA . (2002) Heart and stroke statistical update. Dallas (TX): AHA; 2001;
  2. Levy P, Hornung CA, Haynes JL, Rush DS. Lower extremity ischemia in patients less than forty years of age: a community-wide survey of premature atherosclerotic arterial disease. J Vasc Surg. 1994;19:873–881
  3. Valentine RJ. Premature peripheral atherosclerosis. Cardiovasc Surg. 1993;1(5):473–480
  4. Malinow MR. Homocyst(e)ine and arterial occlusive disease. J Internal Med. 1994;236:603–617
  5. Welch GN, Upchurch GR, Loscalzo J. Homocysteine, oxidative- stress, and vascular disease. Hosp Pract. 1997;32(6):81–92
  6. Bergmark C, Mansoor MA, Swedenborg J, de Faire U, Svardal AM, Ueland PM. Hyperhomocysteinemia in patients operated for lower extremity ischemia below the age of 50: effect of smoking and extent of disease. Eur J Vasc Surg. 1993;7:391–396
  7. Woo K, Chook P, Lolin Y, Cheung A, Chan L, Sun Y, et al.  Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation. 1997;96:2542–2544
  8. Harker L, Ross R, Slichler S, Scott C. Homocysteine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin Invest. 1976;58:731–741
  9. Wall R, Harlan J, Harker L, Striker G. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res. 1980;18:113–121
  10. Stamler J, Osborn J, Jaraki O, Rabbani LE, Mullins M, Singel D, et al.  Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91:308–318
  11. Molgaard J, Malinow MR, Lassvic C, Holm AC, Upson B, Olsson AG. Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication. J Internal Med. 1992;231:273–279
  12. Moustapha A, Robinson K. High plasma homocysteine: a risk factor for vascular disease in the elderly. Coron Artery Dis. 1998;9(11):725–730
  13. Bostom A. Folic acid fortification of food. JAMA. 1996;275(9):681–682
  14. Berwanger CS, Jeremy JY, Stansby G. Homocysteine and vascular disease. Br J Surg. 1995;82:726–731
  15. Halstead C, Villanueva J, Delvin A. Folate deficiency, methionine metabolism, and alcohol liver disease. Alcohol. 2002;27(3):169
  16. Ridker P, Monson J, Buring J, Shih J, Matias M, Hennekens CH. Homocysteine and risk of cardiovascular disease among postmenopausal women. JAMA. 1999;281(19):1817–1821
  17. Glueck CJ, Shaw P, Lang JE, Tracy T, Sieve-Smith L, Wang Y. Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am J Cardiol. 1995;75:132–136
  18. Malinow MR, Nieto FJ, Szklo M, Chanbless LE, Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. Circulation. 1992;87:1107–1113
  19. Morrison HI, Schaubel D, Desmeules M, Wigle DT. Serum folate and risk of fatal coronary heart disease. JAMA. 1996;275(24):1893–1896
  20. Malinow A, Duell P, Hess D, Anderson PH, Kruger WD, Phillipson BE, et al.  Reduction of plasma homocysteine levels by breakfast cereal fortified with folic acid in patients with coronary artery disease. N Engl J Med. 1998;338(15):1009–1015
  21. Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, et al.  Low Circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease and coronary artery disease. JAMA. 1998;97(5):437–443
  22. Granet J, Sanford J, Kohlman-Trigoboff D, Smith B. The effects of high-dose folate and N-acetylcysteine on homocysteine in end-stage renal patients. 2001; (2001, unpublished data)
  23. Hultberg B, Andersson , Sterner G. Plasma homocysteine in renal failure. Clin Nephrol. 1993;40(4):230–234
  24. Welch G, Loscalzo J. Mechanisms of disease: homocysteine and atherothrombosis. N Engl J Med. 1998;338(15):1042–1050

☆ Address reprint requests to Debra Kohlman-Trigoboff, ACNP, CVN, Washington Hospital Center, Section of Vascular Surgery, 110 Irving St, NW NA-1041, Washington, DC 20010.

☆☆ 1062-0303/2003/$30.00 + 0

PII: S1062-0303(02)74501-9

doi: 10.1067/mvn.2003.1

Journal of Vascular Nursing
Volume 21, Issue 1 , Pages 30-32 , March 2003

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